Synthesis and evaluation of bifunctional chelating agents derived from bis (2-aminophenylthio) alkane for radioimaging with 99m Tc

BS Chhikara, N Kumar, V Tandon, AK Mishra

Index: Chhikara, Bhupender S.; Kumar, Nitin; Tandon, Vibha; Mishra, Anil K. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4713 - 4720

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Citation Number: 17

Abstract

Novel bifunctional chelating agents bearing an aromatic rigid backbone have been synthesized and characterized on the basis of spectroscopic techniques. These macrocyclic multidentate chelating agents were conjugated with monoclonal antibody which forms stable complexes with 99mTc with high radiochemical purity.

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