Design, synthesis, and dopamine receptor modulating activity of spiro bicyclic peptidomimetics of L-prolyl-L-leucyl-glycinamide

EM Khalil, WH Ojala, A Pradhan, VD Nair…

Index: Khalil, Ehab M.; Ojala, William H.; Pradhan, Ashish; Nair, Venugopalan D.; Gleason, William B.; Mishra, Ram K.; Johnson, Rodney L. Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 628 - 637

Full Text: HTML

Citation Number: 55

Abstract

In the present study, the synthesis of the 5.5. 6. and 5.6. 5. spiro bicyclic lactam PLG peptidomimetics, compounds 3 and 4, respectively, was undertaken. These peptidomimetics were designed to examine the following:(1) the effect that changing the size of the thiazolidine and lactam ring systems would have on the ability of these systems to mimic the type-II β-turn and (2) the effect that these structural perturbations would have on the ability ...