Carbocyclic thromboxane A2
…, RL Magolda, DA Claremon
Index: Nicolaou; Magolda; Claremon Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1404 - 1409
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Citation Number: 79
Abstract
Abstract: The total synthesis of carbocyclic thromboxane A2 (CTA2)(5) and its hydroxy epimer (5b) has been achieved both in racemic and optically active forms. Bicyclo [3.1. Ilheptan-2-one (6), synthesized by two alternative routes, was converted to the key intermediate 7, which was efficiently transformed to the carbocyclic thromboxane A2 skeleton by a cuprate 1, 4 addition to introduce the lower side chain followed by ...
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