Synthesis of 1, 3-dimethyl-8-(quinuclid-3 1-yl) xanthine and its investigation

GP Zhichareva, LN Yakhontov, MF Marshalkin…

Index: Zhichareva, G. P.; Yakhontov, L. N.; Marshalkin, M. F.; Turchin, K. F.; Kuleshova, E. F.; Sheinker, Yu. N. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 1 p. 22 - 26 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 1 p. 32 - 36

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Abstract

Introduction of an 8-methyl group into the molecule of 1, 3, 7-trimethylaxanthine (caffeine) provided a pharmaceutical compound [3, 4] which has been used to treat cardiovascular diseases and for a long time has taken the place of caffeine in dry medicinal forms. This has led to the extension of research investigations into a large number of 8-substituted methylxanthines [i, 2, 4, 6]. It has recently been reported in the literature [9] that 8- ...