Synthesis and antifungal activities of glycosylated derivatives of the cyclic Peptide fungicide caspofungin

J Guo, H Hu, Q Zhao, T Wang, Y Zou, S Yu…

Index: Guo, Junxiang; Hu, Honggang; Zhao, Qingjie; Wang, Ting; Zou, Yan; Yu, Shichong; Wu, Qiuye; Guo, Zhongwu ChemMedChem, 2012 , vol. 7, # 8 p. 1496 - 1503

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Citation Number: 4

Abstract

Abstract Diseases caused by systemic fungal infections have become a significant clinical problem in recent decades. A series of glycosyl derivatives of the approved cyclic peptide antifungal drug caspofungin conjugated with β-D-glucopyranose, β-D-galactopyranose, β-D- xylopyranose, β-L-rhamnopyranose, β-maltose and β-lactose units were designed, synthesized, and evaluated as new potential antifungal drugs. The compounds were ...