Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 2. Relationship between lipophilicity and antibacterial activity in 5-thiocarbonyl …

R Tokuyama, Y Takahashi, Y Tomita…

Index: Chemical and Pharmaceutical Bulletin, , vol. 49, # 4 p. 353 - 360

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Citation Number: 68

Abstract

... Chemistry 5-Thiourea oxazolidinones 4 and 5-dithio- carbamate oxazolidinones 5 were synthesized as shown in Chart 2. They were prepared from key intermediates 12, which were easily derived from 6 by the usual method.3b) The key ... 2001 Pharmaceutical Society of ... Vol. ...