Design, Synthesis, and Biological Evaluation of 1, 2, 3, 7-Tetrahydro-6 H-purin-6-one and 3, 7-Dihydro-1 H-purine-2, 6-dione Derivatives as Corticotropin-Releasing …

RA Hartz, KK Nanda, CL Ingalls, VT Ahuja…

Index: Hartz, Richard A.; Nanda, Kausik K.; Ingalls, Charles L.; Ahuja, Vijay T.; Molski, Thaddeus F.; Zhang, Ge; Wong, Harvey; Peng, Yong; Kelley, Michelle; Lodge, Nicholas J.; Zaczek, Robert; Gilligan, Paul J.; Trainor, George L. Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4741 - 4754

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Citation Number: 12

Abstract

A growing body of evidence suggests that CRF1 receptor antagonism offers considerable therapeutic potential in the treatment of diseases resulting from elevated levels of CRF, such as anxiety and depression. A series of novel 1, 2, 3, 7-tetrahydro-6 H-purin-6-one and 3, 7- dihydro-1 H-purine-2, 6-dione derivatives was synthesized and evaluated as corticotropin releasing factor-1 (CRF1) receptor antagonists. Compounds within this series, ...