Total synthesis of the polyene macrolide dermostatin A

CJ Sinz, SD Rychnovsky

Index: Sinz, Christopher J; Rychnovsky, Scott D Tetrahedron, 2002 , vol. 58, # 32 p. 6561 - 6576

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Citation Number: 28

Abstract

Herein we provide full details of studies which culminated in the first total synthesis of the polyene macrolide dermostatin A, confirming our earlier stereochemical assignment. A highly convergent synthesis was developed, featuring the cyanohydrin acetonide method for polyol construction and a Stille approach to polyene introduction. The strategies and tactics developed en route should be of value for the preparation of other members of the ...