Chemistry Letters

A practical synthesis of several polyhydroxylated chiral building blocks

M Kusakabe, H Kato, F Sato

Index: Kusakabe, Masato; Kato, Hiroshi; Sato, Fumie Chemistry Letters, 1987 , p. 2163 - 2166

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Citation Number: 6

Abstract

A practical method for the synthesis of several useful polyhydroxylated chiral building blocks has been developed. The key reaction is the kinetic resolution of (E)-1-trimethylsilyl-4-alkoxy- 1-buten-3-ol or (E)-1-trimethylsilyl-5-alkoxy-1-penten-3-ol using the Sharpless asymmetric epoxidation reaction.