Synthesis of non-Natural C2-Homo-ceramide and its apoptotic activity against HL-60 cells
K Shikata, H Niiro, H Azuma, T Tachibana…
Index: Shikata, Keiji; Niiro, Hayato; Azuma, Hideki; Tachibana, Taro; Ogino, Kenji Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 613 - 616
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Citation Number: 17
Abstract
Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from l-aspartic acid via l-homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo-and C2- bishomo-ceramide indicate low but considerable apoptotic activities in comparison with C2- ceramide.
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