Studies on the 1-methyl-4-phenyl-2, 3-dihydropyridinium species 2, 3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nitrostriatal toxin 1-methyl-4- …

…, A Trevor, K Chiba, N Castagnoli Jr

Index: Peterson; Caldera; Trevor; Chiba; Castagnoli Jr. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1432 - 1436

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Citation Number: 58

Abstract

The nigrostriatal toxin l-methyl-l-phenyl-l, 2, 3, 6-tetrahydropyridine (MPTP) is biotransformed by brain monoamine oxidase (MAO) to an unstable dihydropyridinium intermediate that reacts with cyanide ion to form an a-cyanotetrahydropyridine adduct and, in the absence of cyanide ion, undergoes disproportionation to the l-methyl-4- phenylpyridinium species MPP+ and MPTP. Comparison of the HPLC retention times, ...