Novel pyrimidoazepine analogs as serotonin 5-HT 2A and 5-HT 2C receptor ligands for the treatment of obesity

…, J Tae, YW Seo, YJ Kim, HY Im, GD Choi, H Cho…

Index: Yang, Ha Yun; Tae, Jinsung; Seo, Yong Wan; Kim, Yoon Jung; Im, Hye Yeon; Choi, Gil Don; Cho, Heeyeong; Park, Woo-Kyu; Kwon, Oh Seung; Cho, Yong Seo; Ko, Minkyung; Jang, Hyunseo; Lee, Jaeick; Choi, Kihang; Kim, Chan-Hwa; Lee, Jiyoun; Pae, Ae Nim European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 558 - 569

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Citation Number: 9

Abstract

Obesity is one of the most serious public health problems worldwide in the 21st century. Current therapeutic treatment for obesity is mostly focused on preventive measures involving dietary control and physical exercises in combination with anti-obesity medications. However, most of these anti-obesity medications have little or no effect on weight loss, and some cases have demonstrated fatal side effects. Due to the urgent need for highly potent ...