Tetrahedron letters

Aromatic ring favorable and efficient H–D exchange reaction catalyzed by pt/c

…, N Ito, H Esaki, T Maesawa, T Maegawa, K Hirota

Index: Sajiki, Hironao; Ito, Nobuhiro; Esaki, Hiroyoshi; Maesawa, Tsuneaki; Maegawa, Tomohiro; Hirota, Kosaku Tetrahedron Letters, 2005 , vol. 46, # 41 p. 6995 - 6998

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Citation Number: 59

Abstract

An effective and applicable Pt/C-catalyzed deuteration method of aromatic rings using D2O as a deuterium source under hydrogen atmosphere was developed. Five percent Pt/C would lead to quite effective H–D exchange results on the aromatic ring systems. The reaction is general for a variety of aromatic compounds including biologically active compounds.