Asymmetric Synthesis of 2-chloro-and 2-bromo-alkanoic acids by halogenation of α-D-glucofuranose-derived silyl ketene acetals

…, JL Chaumette, JR Desmurs, L Duhamel, G Plé…

Index: Angibaud, P.; Chaumette, J. L.; Desmurs, J. R.; Duhamel, L.; Ple, G.; et al. Tetrahedron: Asymmetry, 1995 , vol. 6, # 8 p. 1919 - 1932

Full Text: HTML

Citation Number: 16

Abstract

Optically active (S)-2-bromo-and 2-chloro-alkanoic acids 6 and 7 have been obtained via the diastereoselective halogenation of chiral silyl ketene acetals 3a-f, and subsequent saponification of the resulting crude esters. Examples characterized by ee values up to 95 ...

Related Articles:

Stereoselektive synthese von D-α-hydroxycarbonsäuren bzw. D-α-hydroxycarbonsäuren enthaltenden depsipeptiden aus L-aminosäuren

[Lerchen, Hans-Georg; Kunz, Horst Tetrahedron Letters, 1985 , vol. 26, # 43 p. 5257 - 5260]

(R)-and (S)-3-hydroxy-4, 4-dimethyl-1-phenyl-2-pyrrolidinone as chiral auxiliaries for the asymmetric synthesis of α-hydroxy acids

[Camps, Pelayo; Perez, Francesc; Soldevilla, Nuria Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1877 - 1894]

More Articles...