Homogeneous hydrogenolysis of the CI bond; Preparation of [5-2 H] uracil

J Roček, V Sváta, L Lešetický

Index: Rocek, Josef; Svata, Vladimir; Leseticky, Ladislav Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1244 - 1248

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Abstract

Hydrogenolysis of halogen derivatives is an important method for the preparation of specifically deuterated or tritiated compounds I ,2. In view of the well-known selectivity3,4 of homogeneously catalysed hydrogenation reactions, compared to the heterogeneous catalysis, we attempted to apply the homogeneous hydrogena- tion to reductive dehalogenation. The chosen substrate was 5-iodouracil, to make the results comparable with the thoroughly studied ...