Highly Diastereo??and Enantioselective Direct Aldol Reactions of Aldehydes and Ketones Catalyzed by Siloxyproline in the Presence of Water

…, N Nagae, T Sumiya, M Shoji, Y Hayashi

Index: Aratake, Seiji; Itoh, Takahiko; Okano, Tsubasa; Nagae, Norio; Sumiya, Tatsunobu; Shoji, Mitsuru; Hayashi, Yujiro Chemistry - A European Journal, 2007 , vol. 13, # 36 p. 10246 - 10256

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Citation Number: 157

Abstract

Abstract Proline-based organocatalysts have been developed for a highly enantioselective, direct aldol reaction of aldehydes and ketones in the presence of water. While several surfactant–proline combined catalysts have proved effective, proline derivatives with a hydrophobic moiety such as trans-siloxy-L-proline and cis-siloxy-D-proline, both of which are easily prepared from the same commercially available 4-hydroxy-L-proline, have been ...