Journal of medicinal chemistry

Aminotetralone analogs of ketamine: synthesis and evaluation of hypnotic and locomotor properties in mice

DJ Yang, JN Davisson

Index: Yang, David J.; Davisson, John N. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1361 - 1365

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Citation Number: 13

Abstract

5'-nucleotide (1 mM), NADH (0.4 mM), glucose 6-phosphate (5.0 mM), glucose &phosphate dehydrogenase (0.6 unit/mL), and 0.25 mL of microsomal suspension in a total volume of 1.25 mL. After 1 h at 37 OC, the incubates were transferred to Amicon Centriflo CF 25 membrane cones (Amicon Corp., Lexington, MA) and centrifuged at 2000 rpm (< 1000g) in a swinging-bucket centrifuge for 75 min at 4" C. The filtrates were analyzed by HPLC on a p- ...