Isoxazolidine-3, 5-diones as lens aldose reductase inhibitors

…, ME Maragoudakis, JS Wasvary

Index: Richon, Allen B.; Maragoudakis, Michael E.; Wasvary, James S. Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 745 - 747

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Citation Number: 23

Abstract

Method A. 2-Methoxy-11-oxo-1 lH-pyrido [t, lb 1-quinazoline-8-carboxamide (16b). A mixture of 2-amino-5-methoxybenzoic acid (27.0 g, 161 mmol), 6-chloro-3-pyridinecarboxamide (25.0 g, 160 mmol), and ethanol (500 mL) containing 15 mL of concentrated HCl was heated at reflux for 24 h. The mixture was cooled to 0" C, and the resultant solid precipitate was collected by filtration to give 34.0 g (69.5%) of crude hydrochloride salt, mp 286-294 OC ...