Thrombus imaging using technetium-99m-labeled high-potency GPIIb/IIIa receptor antagonists. Chemistry and initial biological studies
DA Pearson, J Lister-James, WJ McBride…
Index: Pearson, Daniel A.; Lister-James, John; McBride, William J.; Wilson, David M.; Martel, Lawrence J.; Civitello, Edgar R.; Dean, Richard T. Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1372 - 1382
Full Text: HTML
Citation Number: 69
Abstract
Platelet-specific compounds which are radiolabeled with γ-emitting radionuclides may be particularly useful for the noninvasive in vivo detection of thrombi. The synthesis of peptides which are potent inhibitors of platelet aggregation and which contain a chelator for the radionuclide technetium-99m are described. The target compounds were designed such that stable, oxotechnetium (V) species could be prepared where the site of metal ...
Related Articles:
Rational design of selective thrombin inhibitors
[Kim, Sangsoo; Hwang, Sang Yeul; Kim, Young Kwan; Yun, Mikyung; Oh, Yeong Soo Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 7 p. 769 - 774]
Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption
[Lee, Koo; Jung, Won-Hyuk; Sang, Yeul Hwang; Lee, Sung-Hack Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2483 - 2486]
Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption
[Lee, Koo; Jung, Won-Hyuk; Sang, Yeul Hwang; Lee, Sung-Hack Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2483 - 2486]