Liebigs Annalen der Chemie

Inhibitors of Phenylalanine Ammonia??Lyase: 2??Aminoindan??2??phosphonic Acid and Related Compounds

J Zoń, N Amrhein

Index: Zon, Jerzy; Amrhein, Nikolaus Liebigs Annalen der Chemie, 1992 , # 6 p. 625 - 628

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Citation Number: 124

Abstract

Abstract 2-Aminoindan-2-phosphonic acid (3) was synthesized for the first time both directly from 2-indanone (7) as well as by alkylation of ethyl diethoxyphosphorylacetate with 1, 2-bis (bromomethyl) benzene (9) via 10–12, respectively. 2-Hydroxyindan-2-phosphonic acid (5) was obtained also from 7 via its diisopropyl ester 8. Compound 3 was found to be a potent inhibitor of the plant enzyme phenylalanine ammonia-lyase (EC 4.3. 1.5) both in vitro and ...