Practical large-scale synthesis of the 2-aminomethylpyrrolidin-4-ylthio-containing side chain of the novel carbapenem antibiotic doripenem

Y Nishino, T Komurasaki, T Yuasa…

Index: Organic Process Research and Development, , vol. 7, # 5 p. 649 - 654

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Citation Number: 29

Abstract

... Organic Process Research & Development. ... yield of 49% using our first-generation process (Scheme 2), which was a modification of our previously reported procedure. ... To reduce the cost or the processing time and to make the process more enviromentally suitable, we have ...