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Synthesis of (Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids

M López, Z Rodrı́guez, M González, B Valdés, H Vélez…

Index: Lopez, Miguel; Rodriguez, Zalua; Gonzalez, Maritza; Valdes, Barbara; Velez, Herman; Fini, Adamo Farmaco, 2000 , vol. 55, # 1 p. 40 - 46

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Citation Number: 2

Abstract

(Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids were synthesized by a new method based on the following sequence of reactions: treatment of the tert-butyl acetoacetate with sodium nitrite, alkylation of the oxime formed with an appropriate alkyl halide, halogenation of methyl α-keto group and simultaneous cleavage of tert-butyl ester with sulfuryl chloride, protection of the obtained acid function with diphenyldiazomethane, ...