Organic letters

Magnesium (II)-binaphtholate as a practical chiral catalyst for the enantioselective direct Mannich-type reaction with malonates

M Hatano, T Horibe, K Ishihara

Index: Hatano, Manabu; Horibe, Takahiro; Ishihara, Kazuaki Journal of the American Chemical Society, 2010 , vol. 132, # 1 p. 56 - 57

Full Text: HTML

Citation Number: 50

Abstract

A highly enantioselective direct Mannich-type reaction of aldimines with dialkyl malonates was developed with the use of a Mg (II)-BINOLate salt, which was designed as a cooperative acid base catalyst that can activate both aldimines and malonates. Optically active β- aminoesters and α-halo-β-aminoesters could be synthesized in high yields and with high enantioselectivities. This inexpensive and practical Mg (II)-BINOLate salt could be used in ...