Ligand??Based Design, Synthesis, and Pharmacological Evaluation of 3??Methoxyquinoxalin??2??carboxamides as Structurally Novel Serotonin Type??3 Receptor …

…, S Mundra, DK Pandey, S Bhatt, AK Jindal

Index: Mahesh, Radhakrishnan; Devadoss, Thangaraj; Dhar, Arghya Kusum; Venkatesh, Sudali Muthu; Mundra, Sourabh; Pandey, Dilip Kumar; Bhatt, Shvetank; Jindal, Ankur Kumar Archiv der Pharmazie, 2012 , vol. 345, # 9 p. 687 - 694

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Citation Number: 5

Abstract

Abstract Employing a ligand-based approach, 3-methoxyquinoxalin-2-carboxamides were designed as serotonin type-3 (5-HT 3) receptor antagonists and synthesized from the starting material o-phenylenediamine in a sequence of reactions. The structures of the synthesized compounds were confirmed by spectral data. These carboxamides were investigated for their 5-HT 3 receptor antagonisms in longitudinal muscle myenteric plexus ...