An improved synthesis of anticancer benzothiopyranoindazoles. An efficient large??scale β??aminoethylation procedure
…, AB Giordani, OP Goel, DR Johnson…
Index: Beylin; Colbry; Giordani; Goel; Johnson; Leeds; Leja; Lewis; Lustgarten; Showalter; Sercel; Reily; Uhlendorf; Zisek Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 517 - 527
Full Text: HTML
Citation Number: 8
Abstract
Abstract Improved processes for the synthesis of bulk quantities of the benzothiopyranoindazole clinical agent CI-958 and A-ring congeners is reported. The process chosen for scale-up operations achieves β-aminoethylation of an anilino precursor via a three-step sequence (acylation, reduction, deprotection) starting from N-(trityl) glycine. Detailed analytical data are reported for the target compounds and most intermediates, ...
Related Articles:
[Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539]
[Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539]
[Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539]
[Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539]