Structure–activity relationships of lipopolysaccharide sequestration in N-alkylpolyamines

A Shrestha, D Sil, SS Malladi, HJ Warshakoon…

Index: Shrestha, Anurupa; Sil, Diptesh; Malladi, Subbalakshmi S.; Warshakoon, Hemamali J.; David, Sunil A. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2478 - 2481

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Citation Number: 8

Abstract

We have previously shown that simple N-acyl or N-alkyl polyamines bind to and sequester Gram-negative bacterial lipopolysaccharide, affording protection against lethality in animal models of endotoxicosis. Several iterative design-and-test cycles of SAR studies, including high-throughput screens, had converged on compounds with polyamine scaffolds which have been investigated extensively with reference to the number, position, and length of ...