Solid-phase synthesis of substituted alkynes using the Nicholas reaction

JA Cassel, S Leue, NI Gachkova…

Index: Cassel, Johan A.; Leue, Stefanie; Gachkova, Natalie I.; Kann, Nina C. Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9460 - 9463

Full Text: HTML

Citation Number: 22

Abstract

Combinatorial chemistry and solid-phase synthesis have evolved the last 10 years to become some of the most important techniques for decreasing the time involved in drug development. 1 To reach its full potential, however, solid-phase synthesis has to incorporate the many versatile organometallic reactions developed over recent decades. One example is the Nicholas reaction, 2 creating stable carbocations from propargylic alcohols or ...