Synthesis of the first examples of the imidazo [4, 5-c] isoxazole ring system

CJ Wallis, GW Weaver

Index: Tennant, George; Wallis, Christopher J.; Weaver, George W. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 7 p. 817 - 825

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Abstract

The synthesis of the first examples of the 4-imidazo [4, 5-] isoxazole ring system are reported. These compounds are obtained in good yield by thermolysis of 2-(4-nitro-1- imidazol-5-yl) acetate and malonate derivatives, in turn readily available from reaction of 5- chloro-4-nitro-1-imidazoles with active methylene comp