Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling

S Reyes, RW Huigens III, Z Su, ML Simon…

Index: Reyes, Samuel; Huigens Iii, Robert W.; Su, Zhaoming; Simon, Michel L.; Melander, Christian Organic and Biomolecular Chemistry, 2011 , vol. 9, # 8 p. 3041 - 3049

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Citation Number: 27

Abstract

A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus (MRSA). Results from these studies show that these new derivatives have improved biofilm dispersal activities as well as antibacterial properties against A. baumannii. With MRSA biofilms they are found to possess biofilm inhibition capabilities at low micromolar concentrations.