… of novel bifunctional organocatalysts: Highly enantioselective alcoholysis of meso cyclic anhydrides and its application for synthesis of the key intermediate of P2X 7 …
HJ Yang, FJ Xiong, J Li, FE Chen
Index: Yang, Hong-Jun; Xiong, Fang-Jun; Li, Jie; Chen, Fen-Er Chinese Chemical Letters, 2013 , vol. 24, # 7 p. 553 - 558
Full Text: HTML
Citation Number: 7
Abstract
A family of novel squaramides/sulfamides based on 1, 2-alkamine was developed as chiral bifunctional catalysts to promote the asymmetric alcoholysis of meso cyclic anhydrides. The hemiesters were obtained in high yield with up to 93% ee. The usefulness of this methodology was demonstrated in the asymmetric synthesis of the key intermediate of P2X7 receptor antagonists.
Related Articles:
[Huang, Xiaojun; Zhu, Jiang; Broadbent, Scott Tetrahedron Letters, 2010 , vol. 51, # 12 p. 1554 - 1557]
Solid-phase synthesis of a nonpeptide RGD mimetic library: new selective αvβ3 integrin antagonists
[Sulyok; Gibson; Goodman; Hoelzemann; Wiesner; Kessler Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1938 - 1950]
Solid-phase synthesis of a nonpeptide RGD mimetic library: new selective αvβ3 integrin antagonists
[Sulyok; Gibson; Goodman; Hoelzemann; Wiesner; Kessler Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1938 - 1950]
[Rios-Lombardia, Nicolas; Gotor-Fernandez, Vicente; Gotor, Vicente Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 811 - 819]
[Dey,A.S.; Joullie,M.M. Journal of Organic Chemistry, 1965 , vol. 30, p. 3237 - 3239]