Tetrahedron letters

Chromatography-free product separation in the Mitsunobu reaction

AJ Proctor, K Beautement, JM Clough, DW Knight…

Index: Proctor, Anthony J.; Beautement, Kevin; Clough, John M.; Knight, David W.; Li, Yingfa Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5151 - 5154

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Citation Number: 23

Abstract

Mitsunobu products can be isolated pure without column chromatography by first washing a solution of the crude reaction mixture in dichloromethane with 15% aqueous hydrogen peroxide followed by aqueous sodium sulfite. A final filtration through silica gel secures the pure Mitsunobu product.