An Unexpected Rearrangement in the Application of the Skraup Reaction to 3-Nitro-4-aminoveratrole

KC Frisch, M Silverman, MT Bogert

Index: Frisch; Silverman; Bogert Journal of the American Chemical Society, 1943 , vol. 65, p. 2432

Full Text: HTML

Citation Number: 2

Abstract

In the course of one of our antimalarial research projects, it became necessary to prepare 8- nitro-6, 7-dimethoxyquinoline, and the synthesis which quite naturally suggested itself was the application of the Skraup reaction to 3-nitro-4-aminoveratrole, just as 8-nitro-6- methoxyquinoline is obtained from 3-nitro-4-aniinoanisole in the manufacture of Plasmochin. The preparation of the requisite 3-nitro-4-aminoveratrole from vadlia has ...

Related Articles:

Potent quinoxaline-spaced phosphono. alpha.-amino acids of the AP-6 type as competitive NMDA antagonists: synthesis and biological evaluation

[Baudy, Reinhardt B.; Greenblatt, Lynne P.; Jirkovsky, Ivo L.; Conklin, Mary; Russo, Ralph J.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 331 - 342]

Stable highly oxidizing cobalt complexes of macrocyclic ligands

[Collins, Terrence J.; Powell, Richard D.; Slebodnick, Carla; Uffelman, Erich S. Journal of the American Chemical Society, 1991 , vol. 113, # 22 p. 8419 - 8425]

Lipophilic Metal− Salicylideneimine− Crown Ether Hybrids—Ditopic Carriers in the Facilitated Transport of Amphiphilic Molecules Across Bulk Liquid Membranes

[Pike, Jay D.; Rosa, Dell T.; Coucouvanis, Dimitri European Journal of Inorganic Chemistry, 2001 , # 3 p. 761 - 777]

More Articles...