Novel 1-[2-(diarylmethoxy) ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation

G De Martino, G La Regina, A Di Pasquali…

Index: Ohba, Setsuya; Sakamoto, Takao; Yamanaka, Hiroshi Heterocycles, 1990 , vol. 31, # 7 p. 1301 - 1308

Full Text: HTML

Citation Number: 37

Abstract

... Volume: Page: ... Replacement of one phenyl ring of 1-[2-(diphenylmethoxy)ethyl]-2-methyl-5- nitroimidazole (4) with heterocyclic rings, such as 2 ... 1 WT cell-based assay the racemic 1-{2-[α-(thiophen-2-yl)phenylmethoxy]ethyl}-2-methyl-5-nitroimidazole (7) (EC 50 ...