Chemical Communications

Incorporation of unnatural amino acid derivatives into a peptide bond via an oxime ester catalysed by papain or lipase

ST Chen, CF Tsai, KT Wang

Index: Chen, Shui-Tein; Tsai, Chin-Far; Wang, Kung-Tsung Chemical Communications, 1996 , # 2 p. 165 - 166

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Citation Number: 7

Abstract

In the presence of an oxime in the reaction solution, papain and lipase P (Pseudomonas from Amano) catalysed the stereoselective transesterification of an N-protected amino acid or peptide ester to form an active (oxime) ester which in turn underwent peptide bond formation with several natural and unnatural amino acid derivatives (proline, N- methylglycine, N-methylalanine, α-methylphenylalanine).