Synthesis of new sulfonamides as lipoxygenase inhibitors

…, M Ashraf, I Afzal, SA Shahzad, M Shafiq

Index: Mustafa, Ghulam; Khan, Islam Ullah; Ashraf, Muhammad; Afzal, Iftikhar; Shahzad, Sohail Anjum; Shafiq, Muhammad Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 8 p. 2535 - 2539

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Citation Number: 24

Abstract

The present study describes a convenient method for the synthesis of new lipoxygenase inhibitors, 4-(toluene-4-sulfonylamino)-benzoic acids from p-amino benzoic acid. Reaction of p-amino benzoic acid with p-toluenesulfonyl chloride provided thirteen N-and O-alkylation products 4a–4m in moderate to good yields. Lipoxygenase inhibition of newly formed sulfonamide derivatives was investigated and some of these compounds 4m, 4g, 4e, 4f ...