Pigments of fungi. Part 68. 1 Synthesis and absolute configuration of thysanone 2

CD Donner, M Gill

Index: Donner, Christopher D.; Gill, Melvyn Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 7 p. 938 - 948

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Citation Number: 41

Abstract

The (1 R, 3 S)-absolute stereochemistry of thysanone 1, a fungal benzoisochromanquinone with potent human rhinovirus 3C-protease inhibitory activity, is established for the first time by total synthesis of the natural product from ethyl (S)-lactate and CD comparison with authentic material.