Reactivity of N??benzyl??3??nitrophthalimide: A facile access to isoindolo [1, 2??d][3, 5] benzothiazocine derivatives

A Chihab??Eddine, A Jilale, A Daïch…

Index: Chihab-Eddine; Daich; Jilale; Decroix Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 6 p. 1543 - 1548

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Citation Number: 15

Abstract

Abstract A functionalized isoindolo [1, 2-d][3, 5] benzothiazocine 2B has been synthesized in three steps from the nitro-imide derivative 5. The key step of this sequence was the cyclization of the thioglycolic acid derivative 9 under acidic conditions. An evaluation of the reactivity of the imide 5 and the corresponding N-acyliminium ion toward borohydride reduction, organometallic addition, Meyer-Schuster rearrangement and intermolecular ...