Thiazolecarboxylic acid derivatives. 1. n-substituted 2-amino-4-methylthiazole-5-carboxylic acid derivatives

VV Dovlatyan, KA Eliazyan, VA Pivazyan…

Index: Dovlatyan; Eliazyan; Pivazyan; Kazaryan; Engoyan Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 1 p. 84 - 89

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Abstract

Abstract Acylation of the ethyl ester and anilide of 2-amino-4-methylthiazole-5-carboxylic acid gave 2-acetyl (arylsulfonyl) amino derivatives. Methylation of acetylaminothiazole and subsequent deacetylation gave 2-methylamino-4-methylthiazole-5-carboxylic acid, which was then converted into esters. The ethyl ester and anilide of thiazole-2-carboxylic acid were used as starting compounds for the synthesis of 2-dimethylaminoformimino-and 2- ...