Journal of Heterocyclic Chemistry

Chemistry of thienopyridines. IV. Syntheses of 5??substituted thieno [2, 3??b] pyridines

LH Klemm, R Zell

Index: Klemm,L.H.; Zell,R. Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 773 - 778

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Citation Number: 17

Abstract

Abstract Chemical transformations on 5-acetylthieno [2, 3–6] pyridine produced 5-NH 2, 5- CO 2 H, and 5-CH 2 CO 2 H substituents. The 5-amino compound underwent facile diazotization (plus Sand-meyer reaction), Schiff's base formation, and acylation. Treatment of the derived 5-bromo compound with potassium amide in liquid ammonia gave a mixture of 4-amino (major) and 5-amino isomers. Nmr spectral data are reported for the 5- ...