A short entry to enantiopure 2-substituted 1, 4-benzodioxanes by efficient resolution methods

C Bolchi, L Fumagalli, B Moroni, M Pallavicini…

Index: Bolchi, Cristiano; Fumagalli, Laura; Moroni, Barbara; Pallavicini, Marco; Valoti, Ermanno Tetrahedron Asymmetry, 2003 , vol. 14, # 23 p. 3779 - 3785

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Citation Number: 38

Abstract

(R)-1, 4-Benzodioxane-2-carboxilic acid (R)-1 was obtained by resolution of the racemic acid 1 with stoichiometric or nonstoichiometric (+)-dehydroabietylamine (+)-2 in high chemical yield and enantiomeric excess.(S)-1 was isolated from the mother liquors of the crystallisation of (R)-1·(+)-2 and its enantiomeric excess maximised by recrystallisation procedures involving a precipitation under kinetic control or, alternatively, by conversion ...