Arkivoc

Synthesis of phidianidine B, a highly cytotoxic 1, 2, 4-oxadiazole marine metabolite

…, D Pagano, M Carbone, ML Ciavatta, M Gavagnin

Index: Manzo, Emiliano; Pagano, Dario; Carbone, Marianna; Ciavatta, M. Letizia; Gavagnin, Margherita Arkivoc, 2012 , vol. 2012, # 9 p. 220 - 228

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Citation Number: 5

Abstract

Abstract Phidianidine B (1), a natural 1, 2, 4-oxadiazole linking both an indole system and an aminoalkyl guanidine group that has been recently reported from a marine mollusk, has been synthesized in seven steps (14% total yield). The synthetic procedure, which is based on the coupling of 3-indolacetic acid methyl ester and the amino-alkyl hydroxy guanidine intermediate 2, opportunely prepared, is of general application and allows the synthesis of ...