Tetrahedron Letters

A new synthesis of 2, 8-disubstituted pyrazolo [4, 3-e][1, 2, 4] triazolo [1, 5-c] pyrimidines

AV Dolzhenko, G Pastorin, AV Dolzhenko, WK Chui

Index: Dolzhenko, Anton V.; Pastorin, Giorgia; Dolzhenko, Anna V.; Chui, Wai Keung Tetrahedron Letters, 2009 , vol. 50, # 40 p. 5617 - 5621

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Citation Number: 15

Abstract

A practical synthesis of pyrazolo [4, 3-e][1, 2, 4] triazolo [1, 5-c] pyrimidines, which are key intermediates in the preparation of adenosine receptor antagonists, is developed. The method allows introduction of a variety of aryl substituents at position 2 of the pyrazolo [4, 3- e][1, 2, 4] triazolo [1, 5-c] pyrimidine system via cyclocondensation of 5-amino-4- iminopyrazolo [3, 4-d] pyrimidine with benzaldehydes accompanied with oxidation by ...