Tetrahedron

Solid phase synthesis of an extensively focused library of thiadiazole ethers

J Pernerstorfer, M Brands, H Schirok, B Stelte-Ludwig…

Index: Pernerstorfer, Josef; Brands, Michael; Schirok, Hartmut; Stelte-Ludwig, Beatrix; Woltering, Elisabeth Tetrahedron, 2004 , vol. 60, # 39 p. 8627 - 8632

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Citation Number: 6

Abstract

An approach to combine the advantages of random and of focused combinatorial libraries in pharmaceutical research is described with the example of a solid phase synthesis of 2, 5- disubstituted thiadiazole ethers. Key steps of synthesis are the introduction of the heterocycle by selective, sequential nucleophilic double substitution of 2, 5-bis (methylsulfonyl)-1, 3, 4-thiadiazole and the oxidation of the benzylsulfanyl-1, 3, 4- ...