Tetrahedron

MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines

CE Bell, AY Shaw, F De Moliner, C Hulme

Index: Bell, Christan E.; Shaw, Arthur Y.; De Moliner, Fabio; Hulme, Christopher Tetrahedron, 2014 , vol. 70, # 1 p. 54 - 59

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Citation Number: 10

Abstract

Abstract A tunable microwave-assisted protocol for the synthesis of two biologically relevant families of heterocycles has been designed. Via a simple switch of reaction conditions, the same starting materials can be engaged in either an improved synthesis of the dihydrotriazine scaffold or a novel, first-in-class MCR to render the challenging 5- aminoimidazole nucleus in a single step. An additional first-in-class MCR is also reported ...