Syntheseversuche in der Griseofulvinreihe. 3. Mitteilung. Eine neue Ringöffnung bei Dehydrogriseofulvin
E Kyburz, J Würsch, A Brossi
Index: Kyburz,E. et al. Helvetica Chimica Acta, 1962 , vol. 45, p. 813 - 819
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Citation Number: 4
Abstract
Abstract (−)-Dehydrogriseofulvin (I) is converted to the diphenylether derivatives IV or VIII, respectively, by action of a base or an acid. The mechanism of the basic ring opening reaction has been established by use of 14 C labelled methanol. In the case of the epimerisation of griseofulvin (II) under the influence of methylate, however, it is shown that a more complicated mechanism is involved.
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