Preparation and Investigation of Vitamin B6??Derived Aminopyridinol Antioxidants

…, L Valgimigli, S Culbertson, CL Rector…

Index: Serwa, Remigiusz; Nam, Tae-Gyu; Valgimigli, Luca; Culbertson, Sean; Rector, Christopher L.; Jeong, Byeong-Seon; Pratt, Derek A.; Porter, Ned A. Chemistry - A European Journal, 2010 , vol. 16, # 47 p. 14106 - 14114

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Citation Number: 33

Abstract

Abstract 3-Pyridinols bearing amine substitution para to the hydroxylic moiety have previously been shown to inhibit lipid peroxidation more effectively than typical phenolic antioxidants, for example, α-tocopherol. We report here high-yielding, large-scale syntheses of mono-and bicyclic aminopyridinols from pyridoxine hydrochloride (ie, vitamin B 6). This approach provides straightforward, scaleable access to novel, potent, molecular scaffolds ...