Tetrahedron letters

New facile and mild synthesis of 2-substituted oxazolopyridines

S Heuser, M Keenan, AG Weichert

Index: Heuser, Stefan; Keenan, Martine; Weichert, Andreas G. Tetrahedron Letters, 2005 , vol. 46, # 52 p. 9001 - 9004

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Citation Number: 27

Abstract

A new, two-step synthesis of oxazolopyridines is described. The synthesis involving amide formation between o-aminopyridinols and aliphatic or aromatic carboxylic acids followed by condensation with hexachloroethane/triphenylphosphine takes place at room temperature and thereby gives mild access to all regioisomeric, 2-substituted oxazolopyridines in good yields.