Molecules

Cytotoxic and insecticidal activities of derivatives of harmine, a natural insecticidal component isolated from Peganum harmala

Y Zeng, Y Zhang, Q Weng, M Hu, G Zhong

Index: Zeng, Yong; Zhang, Yaomou; Weng, Qunfang; Hu, Meiying; Zhong, Guohua Molecules, 2010 , vol. 15, # 11 p. 7775 - 7791

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Citation Number: 19

Abstract

Abstract In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, a simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and a series of 1, 3-substituted β-carboline derivatives have been synthesized and evaluated for their cytotoxicity against insect cultured Sf9 cell line in vitro and insecticidal activities against 4th instar larvae of mosquitos, Culex pipiens ...