[N-quaternary derivatives of tilorone]

W Schulze, G Letsch, W Gutsche, K Wohlrabe…

Index: Schulze; Letsch; Gutsche; et al. Pharmazie, 1984 , vol. 39, # 5 p. 320 - 322

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Citation Number: 2

Abstract

Tilorone (free base) reacts with alkyl halides forming quaternary ammonium salts. Bis-as well as mono quaternary compounds (2 resp. 3) were synthesized. The tilorone-bis- methoiodide (2a) was converted to several carbonyl derivatives (4 and 5). All produced compounds did not show any cytostatic activity against the murine leukemias L 1210 and P 388 in vivo. Especially the bis-quaternary derivatives 2 were highly toxic in the mouse.