Tetrahedron

Versatile synthesis of 4-spiro-β-lactam-3-carbonitriles via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl) cyanoacetamides

H Abdellaoui, J Xu

Index: Abdellaoui, Hassane; Xu, Jiaxi Tetrahedron, 2014 , vol. 70, # 29 p. 4323 - 4330

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Citation Number: 8

Abstract

Abstract A series of 4-spiro-cyclohexadienonyl-β-lactam-3-carbonitriles, 2, 7-dioxo-1- azaspiro [3.5] nona-5, 8-diene-3-carbonitriles, was synthesized in satisfactory to excellent yields via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)